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Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications
Perry G. Wang
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Últimas novedades cromatografía
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This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President’s Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.
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Preface Editors Contributors Aqueous Normal-Phase Chromatography: The Bridge between Reversed-Phase and HILIC, Joseph J. Pesek and Maria T. Matyska Application of the Calculated Physicochemical Property, Log D, to Hydrophilic Interaction Chromatography in the Bioanalytical Laboratory, Eugene P. Kadar, Chad E. Wujcik, and Olga Kavetskaia HILIC Behavior of Reversed-Phase/Ion-Exchange Mixed-Mode Stationary Phases and Their Applications, Xiaodong Liu and Christopher A. Pohl Mechanisms Controlling the Separation and Retention of Proanthocyanidins and Other Plant Polyphenols in Hydrophilic Interaction Chromatography, Akio Yanagida and Yoichi Shibusawa Applications of Hydrophilic Interaction Chromatography to Food Analysis, Leticia Mora, Aleida S. Hernández-Cázares, M.-Concepción Aristoy, Fidel Toldrá, and Milagro Reig Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry (HILIC-MS) of Paralytic Shellfish Poisoning Toxins, Domoic Acid, and Assorted Cyanobacterial Toxins, Carmela Dell’Aversano The Application of HILIC for Polar Environmental Contaminants (Including Pharmaceuticals) in Aquatic Systems, Alexander L.N. van Nuijs, Isabela Tarcomnicu, Hugo Neels, and Adrian Covaci Hydrophilic Interaction Chromatography–Mass Spectrometry: An Environmental Application, Kerry M. Peru, Sandra L. Kuchta, John V. Headley,and Allan J. Cessna Clinical Applications of Hydrophilic Interaction Liquid Chromatography, Ping Wang Dimethylarginine Analysis by HILIC-MS/ MS and Its Applications in Clinical Chemistry and In Vivo Animal Models, O. D’Apolito, G. Paglia, M. Zotti, F. Tricarico, L.Trabace, and G. Corso Polar Functional Groups for HILIC Method, Zhigang Hao Analysis of Pharmaceutical Impurities Using Hydrophilic Interaction Liquid Chromatography, Mingjiang Sun and David Q. Liu Fast In-Process Method for the Determination of Ioversol and Related Polar Compounds by Hydrophilic Interaction Chromatography (HILIC) and UPLC, Yuming Chen, Xinqun Huang, Shaoxiong Huang, and Michael Matchett Retention Behavior of Hydrazine Derivatives in HILIC Mode, Juris Hmelnickis, Igors Susinskis, and Kaspars Kokums HILIC Retention Behavior and Method Development for Highly Polar Basic Compounds Used in Pharmaceutical Synthesis, Minhui Ma and Min Liu Retention of Polar Acidic and Basic Drugs by HILIC, Mohammed Shahid Ali and Aamer Roshanali Khatri Retention and Selectivity of Polar Stationary Phases for Hydrophilic Interaction Chromatography, Yong Guo HILIC-MS/MS for the Determination of Polar Bioactive Substances: Representative Applications in the Fields of Pharmacokinetics and Metabolic Profiling, Yannis L. Loukas and Yannis Dotsikas Method Development and Analysis of Mono- and Diphosphorylated Nucleotides by HILIC HPLC-ESI-MS, Samuel H. Yang, Hien P. Nguyen, and Kevin A. Schug Hydrophilic Interaction Liquid Chromatography–Based Enrichment Protocol Coupled to Mass Spectrometry for Glycoproteome Analysis, Cosima Damiana Calvano Development and Application of Methods for Separation of Carbohydrates by Hydrophilic Interaction Liquid Chromatography, Goran Karlsson Hydrophilic Interaction Liquid Chromatography in the Characterization of Glycoproteins, Joanne E. Nettleship Analysis of Protein Glycosylation and Phosphorylation Using HILIC-MS, Morten Thaysen-Andersen, Kasper Engholm-Keller,and Peter Roepstorff Index
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