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ESSENTIAL GENETICS A GENOMICS PERSPECTIVE
Daniel L. Hartl
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Últimas novedades biología
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Updated throughout to reflect the latest discoveries in this fast-paced field, Essential Genetics: A Genomics Perspective, Sixth Edition, provides an accessible, student-friendly introduction to modern genetics. Designed for the shorter, less comprehensive course, this edition presents carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. It goes on to discuss the development and progression of genetics as a field of study within a societal and historical context. The text includes new learning objectives within each chapter which help students identify what they should know as a result of their studying and highlights the skills they should acquire through various practice problems. New Learning Objectives within each chapter help students to: • Identify what they should know or be able to do as a result of their study • Focus on the knowledge they should have acquired from studying the chapter • Guide them to identify and use key concepts including application, analysis, and synthesis • Highlight the skill they should acquire through practice of various problem types |
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•How the complementation test is used to determine whether two mutations have defects in the same gene • New data showing that the folding of interphase chromatin into chromosome territories has the form of a fractal globule. • New section discussing how copy-number variation in human amylase evolved in response to increased dietary starch. • Latest information on hazards of polycarbonate food containers; also a new section on the genetics of schizophrenia and autism. • Revised section on restriction mapping and the newest massively parallel DNA sequencing technologies that can yield the equivalent of 200 human genomes’ worth of DNA sequence in a single sequencing run • Updated with a shortened and streamlined discussion of recombination in bacteriophage • New discoveries concerning the mechanisms of intrinsic transcriptional termination as well as rho-dependent termination • New section on stochastic effects on gene expression and an expanded discussion of the lactose operon. There is also a revised discussion of galactose gene regulation in yeast, as well as new sections on long noncoding RNAs • New sections on ancient DNA sequences of the Neandertal and Denisovan genomes • Examination of master control genes in development • New section on the repair of double-stranded breaks in DNA by nonhomologous end joining or template-directed gap repair • Extensive revision and the latest data on cancer. • New section on the detection of natural selection, as well as a new |
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