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Viral Nanotechnology
Yury Khudyakov, Paul Pumpens
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Últimas novedades biotecnología nanotecnología
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Viral Nanotechnology presents an up-to-date overview of the rapidly developing field of viral nanotechnology in the areas of immunology, virology, microbiology, chemistry, physics, and mathematical modeling. Its chapters are by leading researchers and practitioners, making it both a comprehensive and indispensable resource for study and research.
The field of viral nanotechnology is new and quickly expanding due to increasing demand of the applications already developed. The editors identify viral nanotechnology as a significant science that concerns itself with how to use the molecular modules that the distinctly different science of molecular engineering only constructs. The current potential applications of viral technology are manifold, with opportunities to revolutionize practices in photonics, catalysis, electronics, energy, biomedicine, health care, and public health.
This book emphasizes using viral nanotechnology to improve health. A special emphasis is placed upon using viral nanotechnology for developing vaccines. In addition, it documents viral nanotechnology’s use as a powerful tool for developing drugs and genetic therapies. There is also great potential in its use as a means for diagnostics, including the development of diagnostic reagents and novel imaging technologies for detecting disease and infectious agents.
Viral nanotechnology’s rapid and exciting growth is due to the need for new tools in the prevention, diagnosis, and treatment of disease. The contributors to this volume approach each chapter with the hope that their research and practices will contribute to an improvement in health and life on an unprecedented scale in human history. |
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Preface
Editors
Contributors
Introduction
Introduction to Capsid Architecture
Kaspars Tars
Self-Assembling Virus-like and Virus-Unlike Particles
Adam Zlotnick, Samson Francis, Lye Siang Lee, and Joseph Che-Yen Wang
Electron Cryomicroscopy and Image Reconstruction of Viral Nanoparticles
Bettina Böttcher
X-Ray Analysis of Viral Nanoparticles
Kaspars Tars
Computational Methods for Engineering Protein 3D Nanoobjects
James Lara and Xiaojun Xu
Viral Nanoparticles: Principles of Construction and Characterization
Andris Zeltins
Immunology of Virus-like Particles
Martin F. Bachmann and Franziska Zabel
Nanomedicine: General Considerations and Examples
Kenza Snoussi and Michael Kann
Virus-like Particles: A Versatile Tool for Basic and Applied Research on Emerging and Reemerging Viruses
Sandra Diederich, Alma Gedvilaite, Aurelija Zvirbliene, Andris Kazaks, Kestutis Sasnauskas, Nicholas Johnson, and Rainer G. Ulrich
Virus-like Particles Derived from Hepatitis Viruses
Wolfram H. Gerlich
History and Potential of Hepatitis B Virus Core as a VLP Vaccine Platform
Hadrien Peyret, Sam Stephen, Nicola J. Stonehouse, and David J. Rowlands
SplitCore: Advanced Nanoparticulate Molecular Presentation Platform Based on the Hepatitis B Virus Capsid
Philipp Kolb, Thi Thai An Nguyen, Andreas Walker, and Michael Nassal
Use of VLPs in the Design of Malaria Vaccines
David Whitacre, Diego Espinosa, Darrell Peterson, Fidel Zavala, and David Milich
Use of HBcAg as an Adjuvant in DNA-Based Vaccines: An Unexpected Journey
Matti Sällberg
Bacteriophage Virus-like Particles as a Platform for Vaccine Discovery
Bryce Chackerian and David S. Peabody
Production of Virus-like Particles in Plants
Pooja Saxena and George P. Lomonossoff
Bionanomaterials from Plant Viruses
Alaa A.A. Aljabali and David J. Evans
Assembly of Bluetongue Virus-like Particle: Multiprotein Complex and Its Use as Vaccine
Avnish Patel and Polly Roy
Virus-like Particles Based on Polyomaviruses and Human Papillomaviruses as Vectors for Vaccines, Preventive and Therapeutic Immunotherapy, and Gene Delivery
Tina Dalianis
Applications of Viral Nanoparticles Based on Polyomavirus and Papillomavirus Structures
Jirina Suchanová, Hana Španielová, and Jitka Forstová
Nanoparticles of Norovirus
Ming Tan and Xi Jiang
Virus-like Particle Enzyme Encapsulation: Confined Catalysis and Metabolic Materials
Benjamin Schwarz, Dustin Patterson, and Trevor Douglas
Principles of Design of Virus Nanoparticles for Imaging Applications
Irina Tsvetkova and Bogdan Dragnea
Enveloped Viruses with Single-Stranded Negative RNA Genome as Objects and Subjects of VLP Nanotechnology
Peter Pushko and Paul Pumpens
Traditional and Novel Trends in Influenza Vaccines
Peter Pushko and Terrence M. Tumpey
Retrovirus-Derived Virus-like Particles
Bertrand Bellier, Charlotte Dalba, and David Klatzmann
Cancer Therapy Applying Viral Nanoparticles
Kenneth Lundstrom
Alphaviral Vectors for Cancer Treatment
Anna Zajakina, Jelena Vasilevska, Tatjana Kozlovska, and Kenneth Lundstrom
Synthetic Virus-like Particles in Vaccine Design
Arin Ghasparian and John A. Robinson
Index |
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