Written by renowned professors drawing on their experience gained in the world's most innovative biotechnology market, Japan, this advanced textbook provides an excellent and comprehensive introduction to the latest developments in the field. It provides an array of questions & answers and features numerous applied examples, extending to industrial applications with chapters on medical devices and downstream operations in bioprocesses. Useful for students studying the fundamentals of biochemical engineering, as well as for chemical engineers already working in this vital and expanding field.

PART I: Basic Concepts and Principles INTRODUCTION Background and Scope Dimensions and Units Intensive and Extensive Properties Equilibria and Rates Batch vs. Continuous Operation Material Balance Energy Balance ELEMENTS OF PHYSICAL TRANSFER PROCESSES Introduction Heat Conduction and Molecular Diffusion Fluid Flow and Momentum Transfer Laminar vs. Turbulent Flow Transfer Phenomena in Turbulent Flow Film Coefficients of Heat and Mass Transfer CHEMICAL AND BIOCHEMICAL KINETICS Introduction Fundamental Reaction Kinetics CELL KINETICS Introduction Cell Growth Growth Phases in Batch Culture Factors Affecting Rates of Cell Growth Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF) PART II: Unit Operations and Apparatus for Bio-Systems HEAT TRANSFER Introduction Overall Coefficients U and Film Coefficients h Mean Temperature Difference Estimation of Film Coefficients h Estimation of Overall Coefficients U MASS TRANSFER Introduction Overall Coefficients K and Film Coefficients k of Mass Transfer Types of Mass Transfer Equipment Models for Mass Transfer at the Interface Liquid Phase Mass Transfer with Chemical Reactions Correlations for Film Coefficients of Mass Transfer Performance of Packed Column BIOREACTORS Introduction Some Fundamental Concepts Bubbling Gas-Liquid Reactors Mechanically Stirred Tanks Gas Dispersion in Stirred Tanks Bubble Columns Airlift Reactors Packed-Bed Reactors Microreactors MEMBRANE PROCESSES Introduction Dialysis Ultrafiltration Microfiltration Reverse Osmosis Membrane Modules CELL-LIQUID SEPARATION AND CELL DISRUPTION Introduction Conventional Filtration Microfiltration Centrifugation Cell Disruption STERILIZATION Introduction Kinetics of Thermal Death of Cells Batch Heat Sterilization of Culture Media Continuous Heat Sterilization of Culture Media Sterilizing Filtration ADSORPTION AND CHROMATROGRAPHY Introduction Equilibria in Adsorption Rates of Adsorption into Adsorbent Particles Single- and Multi-Stage Processes for Adsorption Adsorption in Fixed Beds Separation by Chromatography PART III: Practical Aspects in Bioengineering FERMENTOR ENGINEERING Introduction Stirrer Power Requirements for Non-Newtonian Liquids Heat Transfer in Fermentors Gas-Liquid Mass Transfer in Fermentors Criteria for Scaling-Up Fermentors Modes of Fermentor Operation Fermentors for Animal Cell Culture DOWNSTREAM OPERATIONS IN BIOPROCESSES Introduction Separation of Microorganisms by Filtration and Microfiltration Separation by Chromatography Separation in Fixed Beds Sanitation in Downstream Processes MEDICAL DEVICES Introduction Blood and Its Circulation Oxygenation of Blood Artificial Kidney Bioartificial Liver