Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choice of animal species and strains in different research disciplines.

Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requires skillful and conscientious staff. To this end, scientists apply the three R’s: replacing experiments on live animals with alternative methods, reducing the number of animals necessary to obtain valid results within experiments, and refining techniques to minimize the discomfort experienced by the animal participants.

Contents

Preface

Editors

Contributors

Animal Models, Jann Hau

Animal Models for Human Behavior, Steven J. Schapiro

Animal Models for Psychological Disorders, Robert Murison and Anne Marita Milde

Animal Models in Neuroscience, Jesper Mogensen

Induced Animal Models of Parkinson’s Disease, G. A. Smith, E. Murphy, S. B. Dunnett, and E. L. Lane

Animal Models in Aging and Alzheimer’s Disease, Yael H. Edrey and Rochelle Buffenstein

Animal Models in Pain Research, Klas S. P. Abelson and John V. Roughan

Animal Models in Pharmacology and Toxicology, Otto Meyer, Ove Svendsen, and Jens Lykkesfeldt

Animal Models for Otolaryngological Disorders, Mikhail Wadie and Clarence T. Sasaki

Animal Models of Lung Physiology during Anesthesia, Göran Hedenstierna, Görel Nyman, and Claes Frostell

Animal Models of Female Reproduction and Fetal Growth and Development, Anthony M. Carter

Animal Models in Vaccinology, Coenraad F. M. Hendriksen

Animal Models in AIDS Research, K. Jagannadha Sastry, Pramod N. Nehete, Amy N. Courtney, and Danielle R. Fontenot

Animal Models for the Study of Helicobacter Infection, Akira Nishizono

Animal Models in Mycology, Henrik Elvang Jensen

Animal Models in Biodefense Research, Mark A. Suckow and Patrick Sharp

Animal Models in Oral Health Sciences, Björn Klinge and Jörgen Jönsson

Animal Models of Hearing Loss and Tinnitus, Richard Salvi, Edward Lobarinas, Guang-Di Chen, Daniel Stolzberg, and Dalian Ding