Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choice of animal species and strains in different research disciplines. Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requires skillful and conscientious staff. To this end, scientists apply the three R’s: replacing experiments on live animals with alternative methods, reducing the number of animals necessary to obtain valid results within experiments, and refining techniques to minimize the discomfort experienced by the animal participants.

Contents Preface Editors Contributors Animal Models, Jann Hau Animal Models for Human Behavior, Steven J. Schapiro Animal Models for Psychological Disorders, Robert Murison and Anne Marita Milde Animal Models in Neuroscience, Jesper Mogensen Induced Animal Models of Parkinson’s Disease, G. A. Smith, E. Murphy, S. B. Dunnett, and E. L. Lane Animal Models in Aging and Alzheimer’s Disease, Yael H. Edrey and Rochelle Buffenstein Animal Models in Pain Research, Klas S. P. Abelson and John V. Roughan Animal Models in Pharmacology and Toxicology, Otto Meyer, Ove Svendsen, and Jens Lykkesfeldt Animal Models for Otolaryngological Disorders, Mikhail Wadie and Clarence T. Sasaki Animal Models of Lung Physiology during Anesthesia, Göran Hedenstierna, Görel Nyman, and Claes Frostell Animal Models of Female Reproduction and Fetal Growth and Development, Anthony M. Carter Animal Models in Vaccinology, Coenraad F. M. Hendriksen Animal Models in AIDS Research, K. Jagannadha Sastry, Pramod N. Nehete, Amy N. Courtney, and Danielle R. Fontenot Animal Models for the Study of Helicobacter Infection, Akira Nishizono Animal Models in Mycology, Henrik Elvang Jensen Animal Models in Biodefense Research, Mark A. Suckow and Patrick Sharp Animal Models in Oral Health Sciences, Björn Klinge and Jörgen Jönsson Animal Models of Hearing Loss and Tinnitus, Richard Salvi, Edward Lobarinas, Guang-Di Chen, Daniel Stolzberg, and Dalian Ding