This best-selling textbook, known for its prominent authorship, exposes students to the landmark experiments in genetics, teaching them how to analyze experimental data and draw their own conclusions based on scientific thinking.

The 10th edition has been updated with key advances in genetics and cutting-edge experiments and techniques. New co-author John Doebley, a highly respected population geneticist, brings a fresh, student-driven perspective to completely new chapters on Population and Quantitative Genetics. The key chapters on Evolutionary Genetics and The Evolution of Genes and Traits have been heavily revised to reflect recent discoveries in these areas. The end-of-chapter problems have also been revised and updated, giving students great new exercises to test their understanding.

The book is supported by a companion website (www.whfreeman.com/iga10e), which provides online quizzing with feedback and 45 FLASH Animations on core concepts or processes in Genetics.

The Genetics Revolution in the Life Sciences
The nature of biological information
How information becomes biological form
Genetics and evolution
Genetics has provided a powerful new approach to biological research
Model organisms have been crucial in the genetics revolution
Genetics changes society
Genetics and the future

PART I: TRANSMISSION GENETICS

Single-Gene Inheritance
Single-gene inheritance patterns
The chromosomal basis of single-gene inheritance patterns
The molecular basis of Mendelian inheritance patterns
Some genes discovered by observing segregation ratios
Sex-linked single-gene inheritance patterns
Human pedigree analysis

Independent Assortment of Genes
Mendel’s law of independent assortment
Working with independent assortment
The chromosomal basis of independent assortment
Polygenic inheritance
Organelle genes: inheritance independent of the nucleus

Mapping Eukaryote Chromosomes by Recombination
Diagnostics of linkage
Mapping by recombinant frequency
Mapping with molecular markers
Centromere mapping with linear tetrads
Using the chi-square test for testing linkage analysis
Accounting for unseen multiple crossovers
Using recombination-based maps in conjunction with physical maps
The molecular mechanism of crossing over

The Genetics of Bacteria and Their Viruses
Working with microorganisms
Bacterial conjugation
Bacterial transformation
Bacteriophage genetics
Transduction
Physical maps and linkage maps compared

Gene Interaction
Interactions between the alleles of a single gene: variations on dominance
Interaction of genes in pathways
Inferring gene interactions
Penetrance and expressivity

PART II: FROM DNA TO PHENOTYPE

DNA: Structure and Replication
DNA: the genetic material
The DNA structure
Semiconservative replication
Overview of DNA replication
The replisome: a remarkable replication machine
Replication in eukaryotic organisms
Telomeres and telomerase: replication termination

RNA: Transcription and Processing
RNA
Transcription
Transcription in eukaryotes
Intron removal and exon splicing
Small functional RNAs that regulate and protect the eukaryotic genome

Proteins and Their Synthesis
Protein structure
The genetic code
tRNA: the adapter
Ribosomes
The proteome

Gene Isolation and Manipulation
Overview: isolating and amplifying specific gene fragments
Generating recombinant DNA molecules
Finding a specific clone of interest
Determining the base sequence of a DNA segment
Aligning genetic and physical maps to isolate specific genes
Genetic engineering

Regulation of Gene Expression in Bacteria and Their Viruses
Gene regulation
Discovery of the lac system: negative control
Catabolite repression of the lac operon: positive control
Dual positive and negative control: the arabinose operon
Metabolic pathways and additional levels of regulation: attenuation
Bacteriophage life cycles: more regulators, complex operons
Alternative sigma factors regulate large sets of genes

Regulation of Gene Expression in Eukaryotes
Transcriptional regulation in eukaryotes: an overview
Lessons from yeast: the GAL system
Dynamic chromatin
Short-term activation of genes in a chromatin environment
Long-term inactivation of genes in a chromatin environment
Gender-specific silencing of genes and whole chromosomes
Post-transcriptional gene repression by miRNAs

The Genetic Control of Development
The genetic approach to development
The genetic toolkit for Drosophila development
Defining the entire toolkit
Spatial regulation of gene expression in development
Posttranscriptional regulation of gene expression in development
From flies to fingers, feathers, and floor plates: the many roles of individual toolkit genes
Development and disease

Genomes and Genomics
The genomics revolution
Obtaining the sequence of a genome
Bioinformatics: meaning from genomic sequence
The structure of the human genome
Comparative genomics
Functional genomics and reverse genetics

PART III: MUTATION, VARIATION, AND EVOLUTION

The Dynamic Genome: Transposable Elements
Discovery of transposable elements in maize
Transposable elements in prokaryotes
Transposable elements in eukaryotes
The dynamic genome: more transposable elements than ever imagined
Epigenetic regulation of transposable elements by the host

Mutation, Repair, and Recombination
The phenotypic consequences of DNA mutations
The molecular basis of spontaneous mutations
The molecular basis of induced mutations
Biological repair mechanisms
Cancer: an important phenotypic consequence of mutation

Large-Scale Chromosomal Changes
Changes in chromosome number
Changes in chromosome structure
Overall incidence of human chromosome mutations

Population Genetics
Detecting genetic variation
The gene pool concept and the Hardy–Weinberg law
Mating systems
Genetic variation and its measurement
The modulation of genetic variation
Biological and social applications

The Inheritance of Complex Traits
Measuring quantitative variation
A simple genetic model for quantitative variation
Broad sense heritability: nature versus nurture
Narrow sense heritability: predicting phenotypes
Mapping QTL in populations with known pedigrees

Evolution of Genes and Traits
Evolution by natural selection
Molecular evolution: the neutral theory
Natural selection in action: an exemplary case
Cumulative selection and the paths to functional change
Morphological evolution
The origin of new genes and protein functions

A Brief Guide to Model Organisms

Appendix A: Genetic Nomenclature
Appendix B: Bioinformatics Resources for Genetics and Genomics