Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.

Covering the diverse topics that contribute to research in this important field, this book explores:

The mechanisms of lipid oxidation, both enzymatic and non-enzymatic
Antioxidant defenses and lipid oxidation
Lipid oxidation products and cell signaling
The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer
Drug targeting and the therapeutic potential of oxidized lipids
Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

An Introduction to Redox Balance and Lipid Oxidation

Corinne M. Spickett, Maria Fedorova, Ralf Hoffmann, and Henry Jay Forman

CHEMISTRY AND BIOCHEMISTRY OF LIPID OXIDATION

Nonenzymatic Mechanisms of Lipid Oxidation

Claus Schneider and Sean S. Davies

Enzymatic Oxidation of Polyunsaturated Fatty Acids

Sharon A. Murphy, Naser M. I. Al-Aaswad, and Anna Nicolaou

Halogenated Lipids: Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids

David A. Ford

Formation of Nitrated Lipids and Their Biological Relevance

Andrés Trostchansky and Homero Rubbo

Protein Lipoxidation

Koji Uchida

Analysis of Lipid Peroxidation Products in Health and Disease

Michael J. Thomas

SITES OF BIOLOGICAL ACTIONS OF OXIDIZED LIPIDS

Oxidized Lipids as Damage-Associated Molecular Patterns in Inflammatory Responses

Maria Fedorova and Ralf Hoffmann

Formation and Beneficial Roles of Polyunsaturated Lipid Mediators: Lipoxins, Resolvins, Protectins, and Maresins

Nicos A. Petasis

Pro- and Anti-Inflammatory Action of Oxidized Phospholipids

Maria Philippova, Olga Oskolkova, and Valery N. Bochkov

Modulation of Toll-Like Receptor Signaling by Oxidized Phospholipids

Vlad Serbulea and Norbert Leitinger

Dietary Oxidized Lipids as Regulators of Intracellular Signaling Pathways: PPAR and NF-KB

Robert Ringseis, Denise K. Gessner, and Klaus Eder

Oxidized and Nitrated Lipid Interactions with the

Keap1-Nrf2 Pathway

Emilia Kansanen and Anna-Liisa Levonen

OXIDIZED LIPIDS IN PATHOLOGY AND DISEASE

Role of Oxidized Phospholipids in Cardiovascular Disease

Gregor Leibundgut, Adam Taleb, and Sotirios Tsimikas

Cholesterol Oxidation Products in the Initiation, Progression, and Fate of Atherosclerotic Lesions

Giuseppe Poli, Simona Gargiulo, Paola Gamba, Barbara Sottero, Fiorella Biasi, and Gabriella Leonarduzzi

Lipid Peroxidation and Age-Related Neurodegenerative

Disorders

Tanea T. Reed, Zachariah P. Sellers, and D. Allan Butterfield

Association of Oxidative Stress and Lipids with Risk Factors of Metabolic Syndrome

Sampath Parthasarathy, Chandrakala Aluganti Narasimhulu, Irene Fernandez Ruiz, Kathryn Young, Vivek Krishna Pulakazhi Venu, Xueting Jiang, and Aladdin Riad

Oxidized Lipid Products and Carcinogenesis

Françoise Guéraud