Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Covering the diverse topics that contribute to research in this important field, this book explores: The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

An Introduction to Redox Balance and Lipid Oxidation Corinne M. Spickett, Maria Fedorova, Ralf Hoffmann, and Henry Jay Forman CHEMISTRY AND BIOCHEMISTRY OF LIPID OXIDATION Nonenzymatic Mechanisms of Lipid Oxidation Claus Schneider and Sean S. Davies Enzymatic Oxidation of Polyunsaturated Fatty Acids Sharon A. Murphy, Naser M. I. Al-Aaswad, and Anna Nicolaou Halogenated Lipids: Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids David A. Ford Formation of Nitrated Lipids and Their Biological Relevance Andrés Trostchansky and Homero Rubbo Protein Lipoxidation Koji Uchida Analysis of Lipid Peroxidation Products in Health and Disease Michael J. Thomas SITES OF BIOLOGICAL ACTIONS OF OXIDIZED LIPIDS Oxidized Lipids as Damage-Associated Molecular Patterns in Inflammatory Responses Maria Fedorova and Ralf Hoffmann Formation and Beneficial Roles of Polyunsaturated Lipid Mediators: Lipoxins, Resolvins, Protectins, and Maresins Nicos A. Petasis Pro- and Anti-Inflammatory Action of Oxidized Phospholipids Maria Philippova, Olga Oskolkova, and Valery N. Bochkov Modulation of Toll-Like Receptor Signaling by Oxidized Phospholipids Vlad Serbulea and Norbert Leitinger Dietary Oxidized Lipids as Regulators of Intracellular Signaling Pathways: PPAR and NF-KB Robert Ringseis, Denise K. Gessner, and Klaus Eder Oxidized and Nitrated Lipid Interactions with the Keap1-Nrf2 Pathway Emilia Kansanen and Anna-Liisa Levonen OXIDIZED LIPIDS IN PATHOLOGY AND DISEASE Role of Oxidized Phospholipids in Cardiovascular Disease Gregor Leibundgut, Adam Taleb, and Sotirios Tsimikas Cholesterol Oxidation Products in the Initiation, Progression, and Fate of Atherosclerotic Lesions Giuseppe Poli, Simona Gargiulo, Paola Gamba, Barbara Sottero, Fiorella Biasi, and Gabriella Leonarduzzi Lipid Peroxidation and Age-Related Neurodegenerative Disorders Tanea T. Reed, Zachariah P. Sellers, and D. Allan Butterfield Association of Oxidative Stress and Lipids with Risk Factors of Metabolic Syndrome Sampath Parthasarathy, Chandrakala Aluganti Narasimhulu, Irene Fernandez Ruiz, Kathryn Young, Vivek Krishna Pulakazhi Venu, Xueting Jiang, and Aladdin Riad Oxidized Lipid Products and Carcinogenesis Françoise Guéraud