This is an important textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. Written by a team of leading scientists in the field, it covers all the essential aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution — the comparative structural biology. The focus is on interesting and relevant molecular structures as well as central biology.

This comprehensive volume is richly illustrated with more than 200 color figures. So far, there has been a lack of comprehensive textbooks on structural biology that are up to date; this book is written to fill the gap. An accompanying CD contains high-resolution images that can be projected in a classroom.


Contents:
Introduction
Basics of Protein Structure
Basics of Nucleic Acid Structure
The Basics of Lipids and Membrane Structure
Enzymes
Metabolism of DNA: Replication and Recombination
Transcription
Protein Synthesis — Translation
Protein Folding and Degradation
Membrane Proteins
Signal Transduction
Cell Motility and Transport
Structural Aspects of Cell–Cell Interactions
The Immune System
Virus Structure and Function
Structural Biology and the Evolution of Biomacromolecules
Appendices:
Bonds and Energetics of Macromolecules
Methods for Fold Comparison
Prediction of Protein Conformation
Assignment of Function to Proteins
Protein Modification
Nobel Laureates


Readership: Undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine.

TEXTBOOK OF STRUCTURAL BIOLOGY
© World Scientific Publishing Co. Pte. Ltd.
http://www.worldscibooks.com/lifesci/6620.html
vii
CONTENTS
Preface v
Chapter 1: Introduction 1
Chapter 2: Basics of Protein Structure 11
Chapter 3: Basics of Nucleic Acid Structure 59
Chapter 4: The Basics of Lipids and Membrane Structure 123
Chapter 5: Enzymes 159
Chapter 6: Metabolism of DNA: Replication and Recombination 199
Chapter 7: Transcription 221
Chapter 8: Protein Synthesis — Translation 261
Chapter 9: Protein Folding and Degradation 295
Chapter 10: Membrane Proteins 335
Chapter 11: Signal Transduction 367
Chapter 12: Cell Motility and Transport 397
Chapter 13: Structural Aspects of Cell–Cell Interactions 423
TEXTBOOK OF STRUCTURAL BIOLOGY
© World Scientific Publishing Co. Pte. Ltd.
http://www.worldscibooks.com/lifesci/6620.html
viii A Textbook of Structural Biology
Chapter 14: The Immune System 437
Chapter 15: Virus Structure and Function 449
Chapter 16: Structural Biology and the Evolution 465
of Biomacromolecules
Appendix A: Bonds and Energetics of Macromolecules 485
Appendix B: Methods for Fold Comparison 495
Appendix C: Prediction of Protein Conformation 509
Appendix D: Assignment of Function to Proteins 527
Appendix E: Protein Modification 535
Appendix F: Nobel Laureates 549
Index 553