This is an important textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. Written by a team of leading scientists in the field, it covers all the essential aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution — the comparative structural biology. The focus is on interesting and relevant molecular structures as well as central biology. This comprehensive volume is richly illustrated with more than 200 color figures. So far, there has been a lack of comprehensive textbooks on structural biology that are up to date; this book is written to fill the gap. An accompanying CD contains high-resolution images that can be projected in a classroom. Contents: Introduction Basics of Protein Structure Basics of Nucleic Acid Structure The Basics of Lipids and Membrane Structure Enzymes Metabolism of DNA: Replication and Recombination Transcription Protein Synthesis — Translation Protein Folding and Degradation Membrane Proteins Signal Transduction Cell Motility and Transport Structural Aspects of Cell–Cell Interactions The Immune System Virus Structure and Function Structural Biology and the Evolution of Biomacromolecules Appendices: Bonds and Energetics of Macromolecules Methods for Fold Comparison Prediction of Protein Conformation Assignment of Function to Proteins Protein Modification Nobel Laureates Readership: Undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine.

TEXTBOOK OF STRUCTURAL BIOLOGY © World Scientific Publishing Co. Pte. Ltd. http://www.worldscibooks.com/lifesci/6620.html vii CONTENTS Preface v Chapter 1: Introduction 1 Chapter 2: Basics of Protein Structure 11 Chapter 3: Basics of Nucleic Acid Structure 59 Chapter 4: The Basics of Lipids and Membrane Structure 123 Chapter 5: Enzymes 159 Chapter 6: Metabolism of DNA: Replication and Recombination 199 Chapter 7: Transcription 221 Chapter 8: Protein Synthesis — Translation 261 Chapter 9: Protein Folding and Degradation 295 Chapter 10: Membrane Proteins 335 Chapter 11: Signal Transduction 367 Chapter 12: Cell Motility and Transport 397 Chapter 13: Structural Aspects of Cell–Cell Interactions 423 TEXTBOOK OF STRUCTURAL BIOLOGY © World Scientific Publishing Co. Pte. Ltd. http://www.worldscibooks.com/lifesci/6620.html viii
A Textbook of Structural Biology Chapter 14: The Immune System 437 Chapter 15: Virus Structure and Function 449 Chapter 16: Structural Biology and the Evolution 465 of Biomacromolecules Appendix A: Bonds and Energetics of Macromolecules 485 Appendix B: Methods for Fold Comparison 495 Appendix C: Prediction of Protein Conformation 509 Appendix D: Assignment of Function to Proteins 527 Appendix E: Protein Modification 535 Appendix F: Nobel Laureates 549 Index 553