This book gives a review of the author’s previous work on modelling of the processive nucleotide and repeat addition translocations by recombinant Tetrahymena telomerase and proposes an analogous model for recombinant human telomerase. With the models, the dynamics of primer dissociation from the two enzymes and the dynamics of repeat addition translocation by the two enzymes are theoretically studied and compared in detail.

Preface; Introduction; Model for processive nucleotide & repeat addition translocations by Tetrahymena telomerase; Model for processive nucleotide & repeat addition translocations by human telomerase; Equation to describe translocation of reverse transcriptase domain along template; Interaction between DNA primer & TERT; Dynamics of primer dissociation; Dynamics of repeat addition translocation; Repeat addition processivity; Some comments; Summary & outlook; Index.