Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are a-tubulin and ß-tubulin, the proteins that make up microtubules. In this book the authors present topical research in the study of the structure, functions and roles in disease of tubulin. Topics discussed in this compilation include microtubule plus-end tracking proteins in neuronal development and nervous system disorders; trypanosome tubulin molecules as targets for drug and vaccine development for protozoan infections; tubulin inhibitors as vascular disrupting agents and evolution and co-evolution of tubulin’s carboxy

Preface; Microtubule Plus-End Tracking Proteins in Neuronal Development & Nervous System Disorders; Microtubule Organization: The Housekeeping Role of Heat-Shock Proteins & Immunophilins; Trypanosome Tubulin Molecules as Targets for Drug & Vaccine Development for Protozoan Infections; Tubulin: Structure, Function, & Role in Disease; Targeted Disruption of the Tubulin Cytoskeletal Network Activates Expression of the Profibrotic Genes PAI-1 & CTGF: Implications for Vascular Disease; Tubulin Inhibitors as Vascular Disrupting Agents (VDAS); Evolution & Coevolution of Tubulin’s Carboxy-Terminal Tails & Mitochondria; Myelin Basic Protein Interactions with Actin & Tubulin in vitro – Binding, Assembly, & Regulation; Index.