Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.

With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:


•Electron transport and energy production
•Mitochondrial biogenesis and dynamics
•Mitochondrial signaling
•Apoptosis and autophagy
•Pharmacology signaling
•Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Mitochondria—Reactive Oxygen Species (ROS)—Cell Death

A Healthy Free Radical Pessimism: A Glance from an Oxidative Lipidomics Corner; V. E. Kagan, A. A. Shvedova, and Y. Y. Tyurina

Mitochondrial Involvement in the Execution of Cell Death; V. Gogvadze, B. Zhivotovsky, and S. Orrenius

The Role of Protein Kinase C in Mitochondrial Functions in Cardiac Ischemia- Reperfusion Injury; J. C. B. Ferreira and D. Mochly-Rosen

Mitocans, Mitochondria-Targeting Anticancer Drugs: Focus on Mitochondrial Complexes; J. Neuzil, L.-F. Dong, and J. Rohlena

Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance; W. Shen, D. A. Carlson, L. Packer, E. Cadenas, and J. Liu

Mitochondria-Targeted Antioxidants; R. A. J. Smith, R. C. Hartley, and M. P. Murphy


Mitochondria—Metabolism—Nitric Oxide

Lactate Shuttling and the Mitochondrial Lactate Oxidation Complex; G. A. Brooks

Nitric Oxide in the Regulation of Mitochondrial Biogenesis; C. De Palma and E. Clementi

Effect of Sildenafil on Heart Nitric Oxide Metabolism and Mitochondrial Function; T. Zaobornyj, L. B. Valdez, and A. Boveris

Kinases and Mitochondrial Cycling: The Last Encounter; M. C. Carreras and J. J. Poderoso


Acetylation—Deacetylation—Aging

Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics: Implications in Age-Associated Diseases; P. Puigserver and L. Guarente

Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation; L. Valente, R. Szklarczyk, M. A. Huynen, and J. N. Spelbrink

Mitochondrial Regulation by Protein Acetylation; D. B. Lombard, D. X. Tishkoff, and B. M. M.

Zwaans

Calorie Restriction, Mitochondria, and Longevity in Saccharomyces cerevisiae; C. Skinner and S.-J. Lin

Autophagy and Aging: Keeping Organelles and the Proteome Healthy; J. L. Schneider and A. M. Cuervo


Neurodegeneration

Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration; A. Zorzano, J. Segalés, M. I. Hernández-Alvarez, and E. Sorianello

Mitochondrial Abnormalities and Oxidative Stress in Alzheimer’s Disease: Can Mitochondrial Reactive Oxygen Species Signaling Promote Neuronal Survival? P. I. Moreira and C. R. Oliveira

The Role of Mitochondria in Parkinson’s Disease and Huntington’s Disease; A. H. V. Schapira

a-Ketoglutarate Dehydrogenase Complex in Neurodegeneration; G. E. Gibson, A. Starkov, Q. Shi, and M. Flint Beal

R-a-Lipoic Acid as a Potent Agent of Mitochondrial Protection in Alzheimer’s Disease; D. J. Bonda, M. A. Smith, G. Perry, H.-g. Lee, X. Wang, and X. Zhu

Mitochondrial Antioxidants in Neuroprotection; G. Fiskum and M. D. Laird