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The Laboratory Mouse de Peggy J. Danneman, Mark A. Suckow, 9781439854211, CIENCIAS BIOLÓGICAS, biología, Taylor and Francis, Inglés

The Laboratory Mouse

Peggy J. Danneman, Mark A. Suckow

EAN9781439854211

TématicaCiencias biológicas

SubtématicaBiología

EditorialTaylor and Francis

IdiomaInglés

FormatoRústica   Año de publicación2012

 
Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse.

Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.
Important Biological Features

Introduction

Stocks and Strains

Nomenclature

Behavior

Anatomic and Physiologic Features

Normative Values

Hematology

Immunodeficient Mice

Wild Mice

References

Husbandry
Housing

Barriers and Containment

Personal Protective Equipment (PPE)

Special Considerations for Immunodeficient Mice

Environment

Sanitation and Pest Control

Nutrition

Water

Breeding

Identification and Record Keeping

Transportation

References

Management
Regulatory Agencies and Compliance

Institutional Animal Care and Use Committee (IACUC)

Occupational Health and Zoonotic Diseases

References

Clinical Medicine
Basic Veterinary Supplies

Physical Examination of the Mouse

Common Spontaneous and Noninfectious Diseases

Common Infectious Diseases

Treatment and Supportive Care of Sick Mice

Clinical Endpoints

Treating Disease on a Colony Basis

References

Preventive Medicine
Receiving

Testing of Biological Materials

Health Surveillance and Monitoring

Disease Prevention through Sanitation

References

Experimental Methodology
Restraint

Sampling Methods

Compound Administration

Phenotyping

Anesthesia and Analgesia

Euthanasia

Necropsy

References

Resources and Additional Information
Organizations

Publications

Electronic Resources

Appendix A: Glossary of Phenotyping Terminology and Tests

Appendix B: Suggested Cassette Numbering System and Some Trimming Suggestions

Index

PVP:  47,18 €

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